Retro Is Cool: Structure of the Versatile Retromer Complex

Structure. 2020 Apr 7;28(4):387-389. doi: 10.1016/j.str.2020.03.009.


In this issue of Structure, Kendall et al. (2020) reveal the cryo-EM structure of the mammalian retromer complex, which is essential in sorting membrane proteins in endosomes. The retromer heterotrimer can oligomerize in multiple conformations; this versatility is promoted by a flexible interface of electrostatic residues on the VPS35 subunit.

Publication types

  • Comment

MeSH terms

  • Animals
  • Endosomes*
  • Membrane Proteins
  • Protein Transport
  • Vesicular Transport Proteins*


  • Membrane Proteins
  • Vesicular Transport Proteins