NADH Ties One-Carbon Metabolism to Cellular Respiration

Cell Metab. 2020 Apr 7;31(4):660-662. doi: 10.1016/j.cmet.2020.03.012.


In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Carbon
  • Cell Respiration
  • NAD* / metabolism
  • Respiration
  • Serine* / metabolism


  • NAD
  • Serine
  • Carbon