NADH Ties One-Carbon Metabolism to Cellular Respiration

Adam G Maynard; Naama Kanarek

doi:10.1016/j.cmet.2020.03.012

NADH Ties One-Carbon Metabolism to Cellular Respiration

Cell Metab. 2020 Apr 7;31(4):660-662. doi: 10.1016/j.cmet.2020.03.012.

Authors

Adam G Maynard¹, Naama Kanarek²

Affiliations

¹ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
² Department of Pathology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and Massachusetts Institute of Technology, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: naama.kanarek@childrens.harvard.edu.

PMID: 32268110
DOI: 10.1016/j.cmet.2020.03.012

Abstract

In this issue of Cell Metabolism, Yang et al., 2020 report that serine is a source of mitochondrial NADH derived from one-carbon metabolism. Serine becomes a major source of NADH when cellular respiration is inhibited, and the un-utilized, accumulated NADH inhibits the TCA cycle and slows proliferation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Carbon
Cell Respiration
NAD* / metabolism
Respiration
Serine* / metabolism

Substances

NAD
Serine
Carbon