New Microglia on the Block

Cell Metab. 2020 Apr 7;31(4):664-666. doi: 10.1016/j.cmet.2020.03.015.


Microglia exhibit differing functions and phenotypes depending on life stage and the context of health or disease. Recently, in Nature Neuroscience, Marschallinger et al. (2020) described a new state of microglia, namely "lipid-droplet-accumulating microglia" (LDAM), that contributes to neuronal inflammation and age-related neurodegeneration.