Objective: Using Meta-analysis to evaluate the association between Pin1 gene polymorphism at -842 loci and cancer susceptibility. Methods: Pin1, polymorphism, tumor, variant and cancer as key words were used to systematically search for the case-control research on the association between the -842G/C polymorphisms of Pin1 and cancer susceptibility through China National Knowledge Infrastructure (CNKI), Wanfang Data, Embase and PubMed. The time of literatures was up to April 2(nd), 2019. Heterogeneity test, combined risk of cancer with the -842 C allele of Pin1, publication bias test and sensitivity analysis were performed by using Stata 12.0 software. Results: A total of 144 articles were retrieved. According to the inclusion criteria, a total of 11 articles were included (2 Chinese documents and 9 English documents). There were 5 667 cases and 6 120 controls in eligible articles. The heterozygous model showed that Pin1 (-842G/C) polymorphism was associated with cancer susceptibility, and the pooled OR (95%CI) value was 0.78 (0.61, 0.99). Subgroup analysis by cancer type suggested that the Pin1 (-842G/C) polymorphism could significantly decrease the incidence of breast cancer and lung cancer under the heterozygous model (GC vs GG), dominant model (GC+CC vs GG) and allele model (C vs G). The pooled OR (95%CI) values were 0.73 (0.58, 0.92), 0.71 (0.57, 0.89), and 0.73 (0.60, 0.89) in breast cancer and 0.64 (0.52, 0.78), 0.64 (0.53, 0.78), and 0.67 (0.55, 0.80) in lung cancer. The variant -842 C allele could significantly increase the risk of nasopharyngeal carcinoma under the homozygote model (CC vs GG) and recessive model (CC vs GG+GC). The pooled OR (95%CI) values were 2.22 (1.03-4.75) and 2.47 (1.16-5.26). No significant association was observed in squamous cell carcinoma. Conclusion: This Meta-analysis demonstrated that Pin1gene polymorphism at -842 was associated with cancer susceptibility.
目的： 采用Meta分析方法探讨Pin1基因-842G/C位点多态性与肿瘤易感性的关联。 方法： 以中文检索词多态性、癌及英文检索词Pin1、polymorphism、tumor、variant、cancer为主题词，系统检索中国知网数据库、万方数据服务平台、Embase和PubMed等数据库截至期为2019年4月2日发表的Pin1基因-842位点多态性与肿瘤易感性的病例-对照研究相关文献。采用Stata 12.0进行Meta分析，进行异质性检验，计算合并风险值并对发表偏倚及敏感性分析进行检验。 结果： 共检索到144篇文献，根据纳入排除标准，共纳入11篇文献（中文文献2篇，英文文献9篇）。累计病例组5 667例，对照组6 120例。Meta分析结果显示，杂合遗传模型中Pin1基因-842位点多态性与肿瘤易感性相关，合并OR（95%CI）值为0.78（0.61~0.99）。肿瘤类型亚组分析结果显示，杂合遗传模型（GC比GG）、显性遗传模型（GC+CC比GG）和等位基因模型（C比G）中Pin1基因-842位C等位基因可能降低乳腺癌、肺癌的发生风险，乳腺癌中OR（95%CI）值分别为0.73（0.58,0.92）、0.71（0.57,0.89）和0.73（0.60,0.89）；肺癌中OR（95%CI）值分别为0.64（0.52，0.78）、0.64（0.53，0.78）、0.67（0.55，0.80）。纯合遗传模型（CC比GG）和隐形遗传模型（CC比GG+GC）中Pin1基因-842位点C等位基因可能增加鼻咽癌的发病风险，其OR（95%CI）值分别为2.22（1.03~4.75）和2.47（1.16~5.26），但未发现其与鳞状细胞癌的发生有关。 结论： Pin1基因-842位点多态性与肿瘤易感性可能相关。.
Keywords: Meta-analysis; Neoplasms; Pin1; Polymorphism, single nucleotide.