ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19

Eur Respir J. 2020 May 14;55(5):2000688. doi: 10.1183/13993003.00688-2020. Print 2020 May.

Abstract

Smokers and those with COPD have increased airway expression of ACE-2, which is the entry receptor for the COVID-19 virus. This may explain the increased risk of severe COVID-19 in these subpopulations and highlight the importance of smoking cessation. https://bit.ly/3bC29es

Publication types

  • Letter

MeSH terms

  • Acute Lung Injury / complications
  • Acute Lung Injury / metabolism
  • Adult
  • Case-Control Studies
  • Cohort Studies
  • Coronavirus Infections / complications
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / metabolism*
  • Coronavirus Infections / prevention & control
  • Epithelium / metabolism*
  • Female
  • Humans
  • Lung / metabolism
  • Male
  • Middle Aged
  • Pandemics / prevention & control
  • Peptidyl-Dipeptidase A / genetics*
  • Peptidyl-Dipeptidase A / metabolism*
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / metabolism*
  • Pneumonia, Viral / prevention & control
  • Pulmonary Disease, Chronic Obstructive / complications
  • Pulmonary Disease, Chronic Obstructive / genetics
  • Pulmonary Disease, Chronic Obstructive / metabolism*
  • RNA-Seq
  • Reproducibility of Results
  • Respiratory System / metabolism*
  • Smokers
  • Smoking / genetics
  • Smoking / metabolism*
  • Smoking Cessation
  • Up-Regulation*

Substances

  • Peptidyl-Dipeptidase A
  • angiotensin converting enzyme 2

Supplementary concepts

  • COVID-19