A family cluster of severe acute respiratory syndrome coronavirus 2 infections

Eur J Clin Microbiol Infect Dis. 2020 Aug;39(8):1611-1615. doi: 10.1007/s10096-020-03880-1. Epub 2020 Apr 8.


Clinical and epidemiological knowledge of 2019 novel coronavirus disease (COVID-19) is limited. We reported a family cluster of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases in Beijing, China. This family comprised three laboratory confirmed cases with clinical symptoms. All three patients had close contact with a relative from Wuhan, Hubei Province. Throat swab samples were all positive for SARS-CoV-2 using real-time reverse transcriptase-polymerase chain reaction assays. Chest computerized tomography revealed ground-glass opacities and consolidation. SARS-CoV-2 infections tend to clusters. Physicians should be aware of contact history so that infected patients can be identified promptly and further spreading prevented.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Betacoronavirus / isolation & purification*
  • COVID-19
  • Combined Modality Therapy
  • Contact Tracing*
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / pathology
  • Coronavirus Infections / therapy
  • Coronavirus Infections / transmission*
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Male
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / pathology
  • Pneumonia, Viral / therapy
  • Pneumonia, Viral / transmission*
  • SARS-CoV-2
  • Tomography, X-Ray Computed
  • Treatment Outcome