The promise of regenerative medicine in the treatment of urogenital disorders

J Biomed Mater Res A. 2020 Aug 1;108(8):1747-1759. doi: 10.1002/jbm.a.36942. Epub 2020 May 6.


Polymers and scaffolds are the most significant tools in regenerative medicine. Urogenital disorders are an important group of diseases that greatly affect the patient's life expectancy and quality. Reconstruction of urogenital defects is one of the current challenges in regenerative medicine. Regenerative medicine, as well as tissue engineering, may offer suitable approaches, while the tools needed are appropriate materials and cells. Autologous urothelial cells obtained from biopsy, bone marrow-derived stem cells, adipose stem cells and urine-derived stem cells that expressed mesenchymal cell markers are the cells that mainly used. In addition, two main types of biomaterials mainly exist; synthetic polymers and composite scaffolds that are biodegradable polymers with controllable properties and naturally derived biomaterials such as extracellular matrix components and acellular tissue matrices. In this review, we present and evaluate the most appropriate and suitable scaffolds (naturally derived and synthetic polymers) and cells applied in urogenital reconstruction.

Keywords: biomaterial; regenerative medicine; scaffold; urogenital disorders.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / therapeutic use
  • Female
  • Female Urogenital Diseases / therapy*
  • Humans
  • Male
  • Male Urogenital Diseases / therapy*
  • Regenerative Medicine* / methods
  • Stem Cell Transplantation
  • Tissue Engineering* / methods
  • Tissue Scaffolds / chemistry


  • Biocompatible Materials