Perinatal HCV Transmission Rate in HIV/HCV Coinfected women with access to ART in Madrid, Spain

PLoS One. 2020 Apr 9;15(4):e0230109. doi: 10.1371/journal.pone.0230109. eCollection 2020.

Abstract

Background: Maternal HIV coinfection is a key factor for mother-to-child transmission (MTCT) of HCV. However, data about HCV MTCT in HIV/HCV-coinfected pregnant women on combined antiretroviral treatment (ART) are scarce. This study assessed the HCV MTCT rate in the Madrid Cohort of HIV-infected women.

Methods: Retrospective study within the Madrid Cohort of HIV-infected pregnant women (2000-2012). Epidemiological, clinical and treatment related variables were analysed for the mother and infant pairs. HCV MTCT rate was determined.

Results: Three hundred thirty-nine HIV/HCV-coinfected women and their exposed infants were recorded. A total of 227 (67%) paired mother-children had available data of HCV follow-up and were included for the analysis. Sixteen children (rate 7.0%, 95%CI 3.7-10.4%) were HCV infected by 18 months of age, none of them coinfected with HIV. HIV/HCV-coinfected pregnant women were mostly of Spanish origin with a background of previous injection drug use. HCV-genotype 1 was predominant. The characteristics of mothers that transmitted HCV were similar to those that did not transmit HCV with respect to sociodemographic and clinical features. A high rate (50%) of preterm deliveries was observed. Infants infected with HCV were similar at birth in weight, length and head circumference than those uninfected.

Conclusion: MTCT rates of HCV among HIV/HCV-coinfected women on ART within the Madrid cohort were lower than previously described. However, rates are still significant and strategies to eliminate any HCV transmission from mother to child are needed.

Publication types

  • Multicenter Study
  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antiretroviral Therapy, Highly Active*
  • Coinfection / transmission*
  • Coinfection / virology*
  • Female
  • HIV Infections / virology*
  • Health Services Accessibility*
  • Hepacivirus / physiology*
  • Hepatitis C / transmission*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Spain

Grant support

This study was supported by the Instituto de Salud Carlos III- Spanish Ministry of Science and Innovation (EC11-130) under The Spanish National Cohort of HIV-infected Children (CoRISpe), included in the Spanish National AIDS Research Network (RIS) [Grant nº RD16/0025/0019 cofounded by “Fondo Europeo de Desarrollo Regional (FEDER)”], and by the “Fundación para la Investigación y Prevención del SIDA en España (FIPSE)” covered by 3049; 362991; 36531/05 and 36737/08 projects. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.