Targeting Plasmepsins-An Achilles' Heel of the Malaria Parasite

Cell Host Microbe. 2020 Apr 8;27(4):496-498. doi: 10.1016/j.chom.2020.03.015.


Recently, two Plasmodium aspartyl proteases were identified as druggable targets impacting parasite survival. In this issue of Cell Host & Microbe, Favuzza et al. describe the optimization of a compound series acting on both targets, heralding the prospect of a new class of antimalarials for clinical studies.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antimalarials*
  • Aspartic Acid Endopeptidases
  • Malaria*
  • Parasites*


  • Antimalarials
  • Aspartic Acid Endopeptidases
  • plasmepsin