Kidney involvement in COVID-19 and rationale for extracorporeal therapies

Nat Rev Nephrol. 2020 Jun;16(6):308-310. doi: 10.1038/s41581-020-0284-7.


The prevalence of direct kidney involvement in novel coronavirus disease (COVID-19) is low, but such involvement is a marker of multiple organ dysfunction and severe disease. Here, we explore potential pathways of kidney damage and discuss the rationale for extracorporeal support with various blood purification strategies in patients who are critically ill with COVID-19.

MeSH terms

  • Acute Kidney Injury / physiopathology
  • Acute Kidney Injury / virology*
  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections / complications*
  • Coronavirus Infections / immunology
  • Coronavirus Infections / therapy
  • Cytokines / immunology
  • Humans
  • Kidney Function Tests
  • Pandemics
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / immunology
  • Pneumonia, Viral / therapy
  • SARS-CoV-2


  • Cytokines