Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease

Physiol Genomics. 2020 May 1;52(5):217-221. doi: 10.1152/physiolgenomics.00033.2020. Epub 2020 Apr 10.
No abstract available

Keywords: deoxyribonuclease I; flagellin; interferon; neutrophil extracellular traps; toll-like receptor 5.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use
  • Apoptosis Regulatory Proteins / metabolism
  • Betacoronavirus / immunology
  • Betacoronavirus / pathogenicity*
  • COVID-19
  • Calcium-Binding Proteins / metabolism
  • Chemotherapy, Adjuvant
  • Coronavirus Infections / complications
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / prevention & control
  • Coronavirus Infections / therapy*
  • Deoxyribonuclease I / metabolism
  • Deoxyribonuclease I / pharmacology
  • Deoxyribonuclease I / therapeutic use
  • Flagellin / administration & dosage
  • Flagellin / immunology*
  • Flagellin / therapeutic use*
  • Humans
  • Immunity, Innate / drug effects
  • Immunity, Innate / immunology*
  • Inflammation / complications
  • Inflammation / immunology
  • Inflammation / pathology
  • Influenza A virus / immunology
  • Interferon-beta / biosynthesis
  • Interferon-beta / immunology
  • Interleukin-18 / immunology
  • Mice
  • Models, Immunological
  • Neutrophils / drug effects
  • Neutrophils / immunology*
  • Neutrophils / metabolism
  • Pandemics / prevention & control
  • Peptides / therapeutic use
  • Pneumonia, Viral / complications
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / prevention & control
  • Pneumonia, Viral / therapy*
  • Pseudomonas aeruginosa / immunology
  • SARS Virus / immunology
  • SARS-CoV-2
  • Toll-Like Receptor 5 / agonists
  • Toll-Like Receptor 5 / immunology*

Substances

  • Antiviral Agents
  • Apoptosis Regulatory Proteins
  • CBLB502
  • Calcium-Binding Proteins
  • Interleukin-18
  • Ipaf protein, mouse
  • Peptides
  • TLR5 protein, human
  • Toll-Like Receptor 5
  • Flagellin
  • Interferon-beta
  • Deoxyribonuclease I