Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease

Physiol Genomics. 2020 May 1;52(5):217-221. doi: 10.1152/physiolgenomics.00033.2020. Epub 2020 Apr 10.

Authors

Rachel M Golonka¹, Piu Saha¹, Beng San Yeoh¹, Saurabh Chattopadhyay², Andrew T Gewirtz³, Bina Joe¹, Matam Vijay-Kumar^{1

2}

Affiliations

¹ UT Microbiome Consortium, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
² Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.
³ Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.

No abstract available

Keywords: deoxyribonuclease I; flagellin; interferon; neutrophil extracellular traps; toll-like receptor 5.

Publication types

Editorial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiviral Agents / pharmacology
Antiviral Agents / therapeutic use
Apoptosis Regulatory Proteins / metabolism
Betacoronavirus / immunology
Betacoronavirus / pathogenicity*
COVID-19
Calcium-Binding Proteins / metabolism
Chemotherapy, Adjuvant
Coronavirus Infections / complications
Coronavirus Infections / immunology*
Coronavirus Infections / prevention & control
Coronavirus Infections / therapy*
Deoxyribonuclease I / metabolism
Deoxyribonuclease I / pharmacology
Deoxyribonuclease I / therapeutic use
Flagellin / administration & dosage
Flagellin / immunology*
Flagellin / therapeutic use*
Humans
Immunity, Innate / drug effects
Immunity, Innate / immunology*
Inflammation / complications
Inflammation / immunology
Inflammation / pathology
Influenza A virus / immunology
Interferon-beta / biosynthesis
Interferon-beta / immunology
Interleukin-18 / immunology
Mice
Models, Immunological
Neutrophils / drug effects
Neutrophils / immunology*
Neutrophils / metabolism
Pandemics / prevention & control
Peptides / therapeutic use
Pneumonia, Viral / complications
Pneumonia, Viral / immunology*
Pneumonia, Viral / prevention & control
Pneumonia, Viral / therapy*
Pseudomonas aeruginosa / immunology
SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus / immunology
Toll-Like Receptor 5 / agonists
Toll-Like Receptor 5 / immunology*

Substances

Antiviral Agents
Apoptosis Regulatory Proteins
CBLB502
Calcium-Binding Proteins
Interleukin-18
Ipaf protein, mouse
Peptides
TLR5 protein, human
Toll-Like Receptor 5
Flagellin
Interferon-beta
Deoxyribonuclease I

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