Case Report: Death due to COVID-19 in Three Brothers

Sedigheh Yousefzadegan; Nima Rezaei

doi:10.4269/ajtmh.20-0240

Case Report: Death due to COVID-19 in Three Brothers

Am J Trop Med Hyg. 2020 Jun;102(6):1203-1204. doi: 10.4269/ajtmh.20-0240.

Authors

Sedigheh Yousefzadegan¹, Nima Rezaei^{2

3

4}

Affiliations

¹ Department of Pediatric Respiratory Medicine, Firouzabadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
² Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
³ Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
⁴ Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

We report fatal cases of novel coronavirus disease (COVID-19) in three brothers in Iran. An increased susceptibility to specific pathogens has been reported for a number of genetic defects. Considering the fact that most of them who are affected by COVID-19 recover, deaths in three brothers who lived separately and had no known underlying disease suggest genetic predisposition to COVID-19 in some individuals.

Publication types

Case Reports

MeSH terms

Aged
Betacoronavirus / genetics
Betacoronavirus / pathogenicity*
COVID-19
Coronavirus Infections / diagnostic imaging*
Coronavirus Infections / drug therapy
Coronavirus Infections / genetics*
Coronavirus Infections / pathology
Fatal Outcome
Genetic Predisposition to Disease
Humans
Hydroxychloroquine / therapeutic use
Iran
Lung / diagnostic imaging*
Lung / pathology
Lung / virology
Male
Middle Aged
Oseltamivir / therapeutic use
Pandemics
Pneumonia, Viral / diagnostic imaging*
Pneumonia, Viral / drug therapy
Pneumonia, Viral / genetics*
Pneumonia, Viral / pathology
SARS-CoV-2
Siblings
Tomography, X-Ray Computed

Substances

Oseltamivir
Hydroxychloroquine