Low Dose Brain Irradiation Reduces Amyloid-β and Tau in 3xTg-AD Mice

J Alzheimers Dis. 2020;75(1):15-21. doi: 10.3233/JAD-200030.


We have previously reported that low doses of external beam ionizing irradiation reduced amyloid-β (Aβ) plaques and improved cognition in APP/PS1 mice. In this study we investigated the effects of radiation in an age-matched series of 3xTg-AD mice. Mice were hemibrain-irradiated with 5 fractions of 2 Gy and sacrificed 8 weeks after the end of treatment. Aβ and tau were assessed using immunohistochemistry and quantified using image analysis with Definiens Tissue Studio. We observed a significant reduction in Aβ plaque burden and tau staining; these two parameters were significantly correlated. This preliminary data is further support that low doses of radiation may be beneficial in Alzheimer's disease.

Keywords: Amyloid-β; radiation; reduction; tau.

MeSH terms

  • Alzheimer Disease / genetics
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Alzheimer Disease / radiotherapy*
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Brain / metabolism
  • Brain / pathology
  • Brain / radiation effects*
  • Cranial Irradiation / methods*
  • Disease Models, Animal
  • Female
  • Mice
  • Mice, Transgenic
  • tau Proteins / genetics
  • tau Proteins / metabolism*


  • Amyloid beta-Peptides
  • tau Proteins