COMPLETE REMISSION OF MEDICALLY TREATED LUTEINIZED THECOMAS WITH SCLEROSING PERITONITIS

J Gynecol Obstet Hum Reprod. 2021 Jun;50(6):101734. doi: 10.1016/j.jogoh.2020.101734. Epub 2020 Apr 10.

Abstract

We describe the first French patient treated for sclerosing peritonitis syndrome associated with lutheinized thecomas. At 42 years old, she had respiratory distress with increased abdominal volume. Physical examination revealed ascites, pleural effusions, and two mobile latero-uterine masses. Radiological examinations revealed bilateral ovarian masses of 10 cm. Bilateral adnexectomy was performed by laparotomy. Histological analysis concluded that there were benign luteinized thecomas. Until the 36th postoperative day, the general condition of the patient deteriorated to become critical. A second surgical procedure was attempted revealing sclerosing fibrosis preventing access to the peritoneal cavity. Subsequently, a medical treatment combining parenteral nutrition, high intravenous doses of corticosteroids, antiestrogens, colchicine and sandostatin was administered and effective allowing continuity recovery 15 months later. The clinical outcomes has been favorable at 24 month later.

Keywords: medical treatment; sclerosing peritonitis; thecoma.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Colchicine / therapeutic use
  • Estrogen Receptor Modulators / therapeutic use
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Octreotide / therapeutic use
  • Ovarian Neoplasms / complications
  • Ovarian Neoplasms / surgery*
  • Parenteral Nutrition
  • Peritoneum / pathology
  • Peritonitis / complications
  • Peritonitis / therapy*
  • Remission Induction*
  • Sclerosis / complications
  • Sclerosis / therapy*
  • Thecoma / complications
  • Thecoma / surgery*

Substances

  • Antineoplastic Agents, Hormonal
  • Estrogen Receptor Modulators
  • Glucocorticoids
  • Octreotide
  • Colchicine