Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated

Carlos Gustavo Wambier; Andy Goren

doi:10.1016/j.jaad.2020.04.032

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated

J Am Acad Dermatol. 2020 Jul;83(1):308-309. doi: 10.1016/j.jaad.2020.04.032. Epub 2020 Apr 10.

Authors

Carlos Gustavo Wambier¹, Andy Goren²

Affiliations

¹ Department of Dermatology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: carlos_wambier@brown.edu.
² Applied Biology, Inc, Irvine, California.

No abstract available

Keywords: 5-α reductase; ACE2; COVID-19; SARS-CoV-2; TMPRSS2; androgen receptor; androgenetic alopecia; angiotensin converting enzyme 2; antiandrogen therapy; dutasteride; finasteride; human skin; retinoids; transmembrane protease serine 2.

MeSH terms

Androgens / metabolism*
Angiotensin-Converting Enzyme 2
Betacoronavirus / metabolism
Betacoronavirus / pathogenicity*
COVID-19
Chromosomes, Human, X / genetics
Coronavirus Infections / epidemiology
Coronavirus Infections / pathology*
Coronavirus Infections / virology
Genetic Loci
Humans
Pandemics
Peptidyl-Dipeptidase A / genetics
Peptidyl-Dipeptidase A / metabolism
Pneumonia, Viral / epidemiology
Pneumonia, Viral / pathology*
Pneumonia, Viral / virology
Promoter Regions, Genetic / genetics
Receptors, Androgen / genetics
Receptors, Androgen / metabolism
SARS-CoV-2
Serine Endopeptidases / genetics
Serine Endopeptidases / metabolism
Sex Factors
Spike Glycoprotein, Coronavirus / metabolism*
Transcription, Genetic
Viral Load
Virus Internalization*

Substances

AR protein, human
Androgens
Receptors, Androgen
Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, human