The COVID-19 pandemic: implications for the cytology laboratory

J Am Soc Cytopathol. 2020 May-Jun;9(3):202-211. doi: 10.1016/j.jasc.2020.03.001. Epub 2020 Mar 26.

Abstract

The coronavirus disease 2019 (COVID-19) is a pandemic caused by the SARS-CoV-2 virus. The infection has predominantly respiratory transmission and is transmitted through large droplets or aerosols, and less commonly by contact with infected surfaces or fomites. The alarming spread of the infection and the severe clinical disease that it may cause have led to the widespread institution of social distancing measures. Because of repeated exposure to potentially infectious patients and specimens, health care and laboratory personnel are particularly susceptible to contract COVID-19. This review paper provides an assessment of the current state of knowledge about the disease and its pathology, and the potential presence of the virus in cytology specimens. It also discusses the measures that cytology laboratories can take to function during the pandemic, and minimize the risk to their personnel, trainees, and pathologists. In addition, it explores potential means to continue to educate trainees during the COVID-19 pandemic.

Keywords: COVID-19; Coronavirus; Cytology; Pathology education; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • Betacoronavirus / pathogenicity
  • COVID-19
  • Cell Biology / trends*
  • Clinical Laboratory Services / standards*
  • Clinical Laboratory Services / trends
  • Containment of Biohazards / standards
  • Coronavirus Infections / pathology*
  • Coronavirus Infections / prevention & control*
  • Coronavirus Infections / transmission
  • Coronavirus Infections / virology
  • Humans
  • Pandemics / prevention & control*
  • Pneumonia, Viral / pathology*
  • Pneumonia, Viral / prevention & control*
  • Pneumonia, Viral / transmission
  • Pneumonia, Viral / virology
  • SARS-CoV-2
  • Safety
  • Specimen Handling / standards*
  • Specimen Handling / trends