Dynamics of oligomer populations formed during the aggregation of Alzheimer's Aβ42 peptide

Nat Chem. 2020 May;12(5):445-451. doi: 10.1038/s41557-020-0452-1. Epub 2020 Apr 13.


Oligomeric species populated during the aggregation of the Aβ42 peptide have been identified as potent cytotoxins linked to Alzheimer's disease, but the fundamental molecular pathways that control their dynamics have yet to be elucidated. By developing a general approach that combines theory, experiment and simulation, we reveal, in molecular detail, the mechanisms of Aβ42 oligomer dynamics during amyloid fibril formation. Even though all mature amyloid fibrils must originate as oligomers, we found that most Aβ42 oligomers dissociate into their monomeric precursors without forming new fibrils. Only a minority of oligomers converts into fibrillar structures. Moreover, the heterogeneous ensemble of oligomeric species interconverts on timescales comparable to those of aggregation. Our results identify fundamentally new steps that could be targeted by therapeutic interventions designed to combat protein misfolding diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism*
  • Amyloid beta-Peptides / metabolism*
  • Computer Simulation
  • Humans
  • Kinetics
  • Models, Molecular
  • Peptide Fragments / chemistry
  • Peptide Fragments / metabolism*
  • Protein Conformation
  • Protein Folding
  • Protein Multimerization


  • Amyloid beta-Peptides
  • Peptide Fragments
  • amyloid beta-protein (1-42)