The essential role of osteoclast-derived exosomes in magnetic nanoparticle-infiltrated hydroxyapatite scaffold modulated osteoblast proliferation in an osteoporosis model

Nanoscale. 2020 Apr 30;12(16):8720-8726. doi: 10.1039/d0nr00867b.

Abstract

Magnetic hydroxyapatite (MHA) scaffolds promoted osteoblast proliferation in a model of osteoporosis through altering the osteoclast-derived exosomal cargo and decreasing the efficiency of exosome uptake by osteoblasts. Noticeably, certain proteins including ubiquitin, ATP and reactive oxygen species decreased in the osteoclast-derived exosomal cargo with MHA stimulation, while Rho kinase increased.

MeSH terms

  • Animals
  • Cell Proliferation
  • Coculture Techniques
  • Disease Models, Animal
  • Durapatite / chemistry*
  • Durapatite / therapeutic use
  • Exosomes / metabolism*
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / therapeutic use
  • Osteoblasts / cytology*
  • Osteoblasts / metabolism
  • Osteoclasts / metabolism*
  • Osteoporosis / pathology*
  • Osteoporosis / therapy
  • Rats
  • Tissue Scaffolds / chemistry*

Substances

  • Magnetite Nanoparticles
  • Durapatite