Investigation of the influence of thrombophilic genes polymorphism, including serpin 1 (pai-i), fii, prothrombin and itgb3-˩ integrin, on the frequency of stroke in association with controllable risk factors for its occurrence

Wiad Lek. 2020;73(3):471-477.

Abstract

Objective: The aim is the analysis of the relationship between the polymorphism of thrombophilic genes, in particular Serpin 1 (PAI-1), F2-prothrombin and ITGB3-α integrin, and the incidence of stroke, as well as the study of factor effects of this polymorphism in association with controlled risk factors (hypertonic disease, smoking, alcohol consumption, diabetes mellitus, obesity, atrial fibrillation).

Patients and methods: Materials and methods: A total of 134 patients were examined (men accounted for 44.8%, women 55.2%, average age 62.5 ± 2.1). The statistical analysis was carried out using the following criteria: χ2-Pearson, Fisher's exact criterion (reversible), Chuprov's coefficient of conjugation and dispersion analysis (alternative complex).

Results: Results: The relationship between the frequency of a specific allele of thrombophilia and the incidence of stroke is absent. The reason for such results can be a significant effect of random factors (hypertension, diabetes ...), a significant variability of risk factors, their different frequency in groups (inter- and intra-group differences), a significant (95%) total effect of these factors.

Conclusion: Conclusions:Identification of biochemical or genetic markers of thrombophilic conditions, including polymorphism of the hemostasis system genes, will significantly increase the possibility of adequate pathogenetic treatment and timely prevention of acute cerebrovascular disorders, especially persons of working age, which has great medical and social importance.

Keywords: gene; polymorphism; stroke; risk factors; thrombophilia.

MeSH terms

  • Factor V
  • Female
  • Humans
  • Integrin beta3
  • Male
  • Middle Aged
  • Plasminogen Activator Inhibitor 1
  • Prothrombin
  • Risk Factors
  • Serpins
  • Stroke*
  • Thrombophilia*

Substances

  • ITGB3 protein, human
  • Integrin beta3
  • Plasminogen Activator Inhibitor 1
  • Serpins
  • Factor V
  • Prothrombin