Virus infection-induced host mRNA degradation and potential application of live cell imaging

Dan Qi; Jitian Guan; Erxi Wu

doi:10.1016/j.jrid.2018.12.002

Virus infection-induced host mRNA degradation and potential application of live cell imaging

Radiol Infect Dis. 2018 Dec;5(4):143-147. doi: 10.1016/j.jrid.2018.12.002. Epub 2018 Dec 12.

Authors

Dan Qi^{1

2}, Jitian Guan^{1

2}, Erxi Wu^{1

2

3

4

5}

Affiliations

¹ Department of Neurosurgery, Baylor Scott & White Health, Temple, TX 78508, USA.
² Neuroscience Institute, Baylor Scott & White Health, Temple, TX 76502, USA.
³ Department of Surgery, Texas A & M University College of Medicine, Temple, TX 76504, USA.
⁴ Department of Pharmaceutical Sciences, Texas A & M University College of Pharmacy, College Station, TX 77843, USA.
⁵ LIVESTRONG Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA.

Abstract

Viruses exist wherever there is life. They can cause allergy, immune response, inflammation, and even fatal diseases directly or indirectly. Accumulating evidence shows that host RNA undergoes rapid degradation during virus infection. Herein, we focus on several possible mechanisms of infection-induced host RNA turnover, which seems to be a common strategy for both prokaryotic and eukaryotic viruses during the very early stage of infection and a potential application of live cell imaging on its visualization.

Keywords: Bacteriophage; Host infection; Live cell imaging; Messenger RNA decay; Virion.

Publication types

Review