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. 2020 Apr 9;2(2):100118.
doi: 10.1016/j.ajogmf.2020.100118. Online ahead of print.

COVID-19 Infection Among Asymptomatic and Symptomatic Pregnant Women: Two Weeks of Confirmed Presentations to an Affiliated Pair of New York City Hospitals

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COVID-19 Infection Among Asymptomatic and Symptomatic Pregnant Women: Two Weeks of Confirmed Presentations to an Affiliated Pair of New York City Hospitals

Noelle Breslin et al. Am J Obstet Gynecol MFM. .
Free PMC article

Abstract

The novel coronavirus 2019, or COVID-19, infection has rapidly spread through the New York metropolitan area since the first reported case in the state on March 1, 2020. New York currently represents an epicenter for COVID-19 infection in the United States, with 84,735 cases reported as of April 2, 2020. We previously presented an early experience with seven COVID-positive patients in pregnancy, including two women who were diagnosed with COVID-19 following an asymptomatic initial presentation. We now describe a series of 43 test-confirmed cases of COVID-19 presenting to a pair of affiliated New York City hospitals over two weeks from March 13 to 27, 2020. Fourteen (32.6%) patients presented without any COVID-associated viral symptoms, and were identified either after developing symptoms during admission or following the implementation of universal testing for all obstetrical admissions on March 22. Of these, 10/14 (71.4%) developed symptoms or signs of COVID-19 infection over the course of their delivery admission or early after postpartum discharge. Of the other 29 (67.4%) patients who presented with symptomatic COVID-19 infection, three women ultimately required antenatal admission for viral symptoms, and an additional patient represented six days postpartum after a successful labor induction with worsening respiratory status that required oxygen supplementation. There were no confirmed cases of COVID-19 detected in neonates upon initial testing on the first day of life. Applying COVID-19 disease severity characteristics as described by Wu et al, 37 (86%) women possessed mild disease, four (9.3%) exhibited severe disease, and two (4.7%) developed critical disease; these percentages are similar to those described for non-pregnant adults with COVID-19 infections (about 80% mild, 15% severe, and 5% critical disease).

Keywords: COVID-19; novel coronavirus; pregnancy.

Figures

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Figure
Severity of COVID-19 infections in asymptomatic and symptomatic COVID-19–positive patients BID, twice a day; COVID-19, coronavirus disease 2019; ICU, intensive care unit; IV, intravenous; PCR, polymerase chain reaction; PO, by mouth; SARS-Cov-2, severe acute respiratory syndrome coronavirus 2. Breslin et al. COVID-19 in asymptomatic and symptomatic pregnant women. AJOG MFM 2020.

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References

    1. World Health Organization Novel coronavirus—China. http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/ Available at:
    1. Centers for Disease Control and Prevention Coronavirus disease 2019 (COVID-19). Cases in U.S. https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/cases-in-us.html Available at:
    1. Li N., Han L., Peng M. Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study. https://www.medrxiv.org/content/10.1101/2020.03.10.20033605v1 Available at: - DOI - PMC - PubMed
    1. Rasmussen S.A., Jamieson D.J., Bresee J.S. Pandemic influenza and pregnant women. Emerg Infect Dis. 2008;14:95–100. - PMC - PubMed
    1. Breslin N., Baptiste C., Miller R. Coronavirus disease 2019 in pregnancy: early lessons. Am J Obstet Gynecol MFM. 2020;2:100111.
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