Antiviral treatment of COVID-19

Turk J Med Sci. 2020 Apr 21;50(SI-1):611-619. doi: 10.3906/sag-2004-145.

Abstract

Currently, there is not any specific effective antiviral treatment for COVID-19. Although most of the COVID-19 patients have mild or moderate courses, up to 5%–10% can have severe, potentially life threatening course, there is an urgent need for effective drugs. Optimized supportive care remains the mainstay of therapy. There have been more than 300 clinical trials going on, various antiviral and immunomodulating agents are in various stages of evaluation for COVID-19 in those trials and some of them will be published in the next couple of months. Despite the urgent need to find an effective antiviral treatment for COVID-19 through randomized controlled studies, certain agents are being used all over the world based on either in-vitro or extrapolated evidence or observational studies. The most frequently used agents both in Turkey and all over the world including chloroquine, hydroxychloroquine, lopinavir/ritonavir, favipiravir and remdesivir will be reviewed here .Nitazoxanide and ivermectin were also included in this review as they have recently been reported to have an activity against SARS-CoV-2 in vitro and are licensed for the treatment of some other human infections.

Keywords: Covid-19; Sars-CoV-2; antiviral.

Publication types

  • Review

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Alanine / analogs & derivatives
  • Amides
  • Antiviral Agents / therapeutic use*
  • Betacoronavirus
  • COVID-19
  • Chloroquine
  • Coronavirus Infections / drug therapy*
  • Drug Combinations
  • Humans
  • Hydroxychloroquine
  • Ivermectin
  • Lopinavir
  • Nitro Compounds
  • Pandemics
  • Pneumonia, Viral / drug therapy*
  • Pyrazines
  • Ritonavir
  • SARS-CoV-2
  • Thiazoles

Substances

  • Amides
  • Antiviral Agents
  • Drug Combinations
  • Nitro Compounds
  • Pyrazines
  • Thiazoles
  • lopinavir-ritonavir drug combination
  • Lopinavir
  • remdesivir
  • Adenosine Monophosphate
  • Hydroxychloroquine
  • Ivermectin
  • Chloroquine
  • favipiravir
  • Ritonavir
  • Alanine
  • nitazoxanide

Supplementary concepts

  • COVID-19 drug treatment