Measurement of the serum zonulin levels in patients with acne rosacea

J Dermatolog Treat. 2022 Feb;33(1):389-392. doi: 10.1080/09546634.2020.1757015. Epub 2020 Apr 23.


Objective: Although the etiopathogenesis of acne rosacea has not yet been clearly elucidated, it has been discussed over the years that autoimmunity may play a role. Genetic and environmental factors are known to have combined effects in the background of autoimmunity, but it has recently been emphasized that an impaired intestinal barrier system is also involved in the development of the disease. Zonulin is a protein that reversibly increases intestinal permeability. This study aimed to evaluate the zonulin levels in acne rosacea.

Methods: A total of 61 individuals, 30 diagnosed with acne rosacea and 31 healthy controls, were included in this study. There was no difference between the two groups in terms of age, gender, and body mass index. Zonulin was studied using the enzyme-linked immunosorbent assay.

Results: The serum zonulin levels were found to be significantly higher in the patient group than in the control group (18.5 ± 2.9 ng/ml and 13.2 ± 2.7 ng/ml, respectively; p < .001).

Conclusion: This is the first study in the literature to demonstrate that the serum zonulin levels are increased in patients with acne rosacea.

Keywords: Acne rosacea; small intestine; zonulin.

MeSH terms

  • Enzyme-Linked Immunosorbent Assay
  • Haptoglobins
  • Humans
  • Permeability
  • Protein Precursors*
  • Rosacea*


  • Haptoglobins
  • Protein Precursors
  • zonulin