Multiple criteria decision analysis approach to consider therapeutic innovations in the emergency department: The methoxyflurane organizational impact in acute trauma pain

PLoS One. 2020 Apr 15;15(4):e0231571. doi: 10.1371/journal.pone.0231571. eCollection 2020.

Abstract

Background: Acute trauma pain is poorly managed in the emergency department (ED). The reasons are partly organizational: ED crowding and rare trauma care pathways contribute to oligoanalgesia. Anticipating the organizational impact of an innovative care procedure might facilitate the decision-making process and help to optimize pain management.

Methods: We used a multiple criteria decision analysis (MCDA) approach to consider the organizational impact of methoxyflurane (self-administered) in the ED, introduced alone or supported by a trauma care pathway. A MCDA experiment was designed for this specific context, 8 experts in emergency trauma care pathways (leading physicians and pharmacists working in French urban tertiary hospitals) were recruited. The study involved four steps: (i) Selection of organizational criteria for evaluating the innovation's impact; (ii) assessment of the relative weight of each criterion; (iii) choice of appropriate scenarios for exploring the organizational impact of MEOX under various contexts; and (iv) software-assisted simulation based on pairwise comparisons of the scenarios. The final outcome measure was the expected overall organizational impact of methoxyflurane on a 0-to-100 scale (score >50: positive impact).

Results: Nine organizational criteria were selected. "Mean length of stay in the ED" was the most weighted. Methoxyflurane alone obtained 59 as a total score, with a putative positive impact for eight criteria, and a neutral effect on one. When a trauma care pathway was introduced concomitantly, the impact of methoxyflurane was greater overall (score: 75) and for each individual criterion.

Conclusions: Our model highlighted the putative positive organizational impact of methoxyflurane in the ED-particularly when supported by a trauma care pathway-and the relevance of expert consensus in this particular pharmacoeconomic context. The MCDA approach could be extended to other research fields and healthcare challenges in emergency medicine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Pain / diagnosis
  • Acute Pain / drug therapy*
  • Acute Pain / etiology
  • Anesthetics, Inhalation / administration & dosage*
  • Clinical Decision-Making / methods
  • Critical Pathways
  • Crowding
  • Decision Support Techniques*
  • Emergency Service, Hospital / organization & administration*
  • Emergency Treatment / methods
  • France
  • Humans
  • Length of Stay
  • Methoxyflurane / administration & dosage*
  • Models, Organizational
  • Outcome and Process Assessment, Health Care
  • Pain Management / methods
  • Pain Measurement
  • Pilot Projects
  • Self Administration
  • Therapies, Investigational / methods*
  • Time Factors
  • Wounds and Injuries / complications
  • Wounds and Injuries / therapy*

Substances

  • Anesthetics, Inhalation
  • Methoxyflurane

Grants and funding

This work was funded by Mundipharma SAS (Paris, France; www.mundipharma.fr). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.