Physical exercise affects cholinesterases and organophosphate response

Gen Pharmacol. 1988;19(6):815-8. doi: 10.1016/s0306-3623(88)80011-9.

Abstract

1. Cholinesterase activities in blood and tissues of control and exercising rats with and without organophosphate (OP) exposure were studied. 2. Physical exercise increased total cholinesterase and butyrylcholinesterase activities in rats without OP exposure in blood and diaphragm. In brain physical exercise had no effect on acetylcholinesterase activity. 3. Physical exercise diminished cholinesterase inhibition in blood and tissues after OP exposure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / metabolism
  • Animals
  • Brain / enzymology
  • Cholinesterase Inhibitors / pharmacology*
  • Cholinesterases / blood
  • Cholinesterases / metabolism*
  • Diaphragm / enzymology
  • In Vitro Techniques
  • Isoflurophate / pharmacology
  • Male
  • Organophosphorus Compounds / pharmacology*
  • Physical Conditioning, Animal*
  • Rats
  • Rats, Inbred F344
  • Sarin / pharmacology

Substances

  • Cholinesterase Inhibitors
  • Organophosphorus Compounds
  • Isoflurophate
  • Sarin
  • Acetylcholinesterase
  • Cholinesterases