Mechanism of thrombocytopenia in COVID-19 patients

Ann Hematol. 2020 Jun;99(6):1205-1208. doi: 10.1007/s00277-020-04019-0. Epub 2020 Apr 15.

Abstract

Since December 2019, a novel coronavirus has spread throughout China and across the world, causing a continuous increase in confirmed cases within a short period of time. Some studies reported cases of thrombocytopenia, but hardly any studies mentioned how the virus causes thrombocytopenia. We propose several mechanisms by which coronavirus disease 2019 causes thrombocytopenia to better understand this disease and provide more clinical treatment options.

Keywords: Coronavirus disease 2019; Platelet; Severe acute respiratory syndrome coronavirus 2; Thrombocytopenia.

Publication types

  • Review

MeSH terms

  • Betacoronavirus*
  • Coronavirus Infections / blood
  • Coronavirus Infections / complications*
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / therapy
  • Humans
  • Leukopenia / etiology
  • Pandemics
  • Pneumonia, Viral / blood
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / therapy
  • Thrombocytopenia / etiology*
  • Thrombocytopenia / therapy
  • Thrombopoiesis

Supplementary concepts

  • COVID-19
  • COVID-19 drug treatment
  • severe acute respiratory syndrome coronavirus 2