Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes

Arch Immunol Ther Exp (Warsz). 2020 Apr 15;68(2):13. doi: 10.1007/s00005-020-00578-2.


Interactions between the immune system and the pancreas are pivotal in understanding how and why β cells' damage causes problems with pancreas functioning. Pancreatic islets are crucial in maintaining glucose homeostasis in organs, tissue and cells. Autoimmune aggression towards pancreatic islets, mainly β cells, leads to type 1 diabetes-one of the most prevalent autoimmune disease in the world, being a worldwide risk to health of many people. In this review, we highlight the role of immune cells and its influence in the development of autoimmunity in Langerhans islets. Moreover, we discuss the impact of the immunological factors on future understanding possible recurrence of autoimmunity on 3D-bioprinted bionic pancreas.

Keywords: Bioprintig; CRISP/CAS9; Immune cells; Pancreas; Type 1 diabetes.

Publication types

  • Review

MeSH terms

  • Autoimmunity
  • Bioprinting / trends*
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / pathology
  • Diabetes Mellitus, Type 1 / therapy*
  • Humans
  • Immune System / cytology*
  • Insulin-Secreting Cells / cytology
  • Islets of Langerhans / cytology
  • Islets of Langerhans / immunology
  • Islets of Langerhans Transplantation
  • Pancreas / immunology*
  • Pancreas / pathology
  • Stem Cells / cytology*