Clinical characteristics of 225 patients with COVID-19 in a tertiary Hospital near Wuhan, China

J Clin Virol. 2020 Jun;127:104363. doi: 10.1016/j.jcv.2020.104363. Epub 2020 Apr 10.

Abstract

Background: The 2019 coronavirus disease (COVID-19) was first identified in Wuhan, Hubei, China in December 2019, caused by a novel coronavirus (SARS-CoV-2). There is a need to study the clinical features of patients in a hospital near Wuhan.

Objective: To identify clinical features of patients with COVID-19 in a tertiary hospital near Wuhan.

Study design: General information, clinical manifestations, laboratory data, and computed tomography (CT) data were collected for 225 patients diagnosed of COVID-19 admitted between January 20 and February 14, 2020, to the Hanchuan City People's Hospital.

Results: The patients included 120 male and 105 females who had no connection to the Wuhan Huanan Seafood Market. Their average age was 50 ± 14 years. The major clinical symptoms were fever (84.44% of patients), cough (56.44% of patients), and dyspnea (4.00% of patients); 3.56%-22.67% of subjects suffered from expectoration, fatigue, chills, headache, chest pain, and pharyngalgia. Hypertension was present in 20.89% of patients. The counts of white blood cells (WBCs) and lymphocytes were normal or decreased in 86.67% and 99.11% of patients. CRP was increased in 86.22% of patients, PCT in 10.67%, and ESR in 90.22%. CT showed that 86.22% of patients had multiple patchy glassy shadows in both lungs, particularly in the peripheral area. Thirty-seven (16.44%) patients were diagnosed with severe COVID-19. Methylprednisolone was administered in 44.44% of cases. The mortality among the patients was 0.89%.

Conclusions: Clinical characteristics of COVID-19 patients in the tertiary hospital near Wuhan are very similar to those found in Wuhan, but the lower mortality.

Keywords: COVID-19; Coronavirus; RT-PCR; SARS-CoV-2; Viral pneumonia.

MeSH terms

  • Adult
  • Anti-Inflammatory Agents / therapeutic use
  • Betacoronavirus
  • COVID-19
  • China / epidemiology
  • Coronavirus Infections / epidemiology*
  • Cough / virology
  • Dyspnea / virology
  • Female
  • Fever / virology
  • Humans
  • Hypertension / complications
  • Lung / diagnostic imaging
  • Lung / pathology
  • Lung / virology*
  • Lymphocyte Count
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Pandemics
  • Pneumonia, Viral / epidemiology*
  • SARS-CoV-2
  • Tertiary Care Centers / statistics & numerical data*
  • Tomography, X-Ray Computed

Substances

  • Anti-Inflammatory Agents
  • Methylprednisolone