Sensitive fluorescence detection of atorvastatin by doped carbon dots synthesized in deep eutectic media

Spectrochim Acta A Mol Biomol Spectrosc. 2020 Aug 5:236:118341. doi: 10.1016/j.saa.2020.118341. Epub 2020 Apr 3.

Abstract

Fluorescence properties of nanoparticles can be influenced by solvent. In this work, carbon dots (CDs) were synthesized in deep eutectic solvent by microwave assisted method. Quantum yield (QY) and size of the synthesized CDs were 41.3% and 2 nm, respectively. N/Cl -doped CDs had excellent sensitivity and selectivity for atorvastatin and detection limit was 0.8 nM. Simple and low-cost synthesis method and excellent sensitivity are advantages of this detection method for atorvastatin. The as-synthesized N/Cl-doped CDs were successfully used to determine atorvastatin in blood serum.

Keywords: Atorvastatin; Carbon dots; Deep eutectic solvent; Fluorescence; Microwave.

MeSH terms

  • Anticholesteremic Agents / analysis
  • Anticholesteremic Agents / blood
  • Anticholesteremic Agents / chemistry
  • Atorvastatin / analysis*
  • Atorvastatin / blood
  • Atorvastatin / chemistry
  • Carbon / chemistry*
  • Choline / chemistry
  • Fluorescence
  • Glucose / chemistry
  • Humans
  • Hydrogen-Ion Concentration
  • Limit of Detection
  • Microscopy, Electron, Transmission
  • Quantum Dots / chemistry*
  • Solvents / chemistry
  • Spectrometry, Fluorescence / methods*
  • Spectroscopy, Fourier Transform Infrared
  • Time Factors
  • Urea / chemistry

Substances

  • Anticholesteremic Agents
  • Solvents
  • Carbon
  • Urea
  • Atorvastatin
  • Glucose
  • Choline