Human papilloma virus-associated metachronous squamous cell carcinoma of the larynx and uterine cervix: Case report and review of the literature

Semiramis Carbajal-Mamani; Neil Chheda; Ashwini Esnakula; Joel Cardenas-Goicoechea

doi:10.1016/j.gore.2020.100568

Human papilloma virus-associated metachronous squamous cell carcinoma of the larynx and uterine cervix: Case report and review of the literature

Gynecol Oncol Rep. 2020 Apr 7:32:100568. doi: 10.1016/j.gore.2020.100568. eCollection 2020 May.

Authors

Semiramis Carbajal-Mamani¹, Neil Chheda², Ashwini Esnakula³, Joel Cardenas-Goicoechea⁴

Affiliations

¹ University of Florida, Department of Medicine, United States.
² University of Florida, Department of Otolaryngology, United States.
³ University of Florida, Department of Pathology, United States.
⁴ University of Florida, Department of Obstetrics and Gynecology, Division: Gynecologic Oncology, United States.

Abstract

60 year old woman with a history of laryngeal carcinoma-HPV 16 positive, presents seven years later with an abnormal Pap smear. Cervical biopsy showed squamous cell carcinoma. Clinical stage was IB1. Patient underwent open radical hysterectomy and lymphadenectomy. Based on pathologic findings no adjuvant therapy was recommended. Uterine cervix carcinoma was also positive for HPV-16. There are no guidelines for cervical cancer screening in patients with laryngeal cancer and vice versa. Our recommendation is that patient with HPV-positive laryngeal cancer should be encouraged HPV vaccine as current guidelines, but more frequent screening, as recommended for women with specific co-morbid conditions, needs to be investigated. Research is needed to assess the role of screening for laryngeal cancer in women with cervical cancer and the effect of HPV vaccine on laryngeal cancer prevention.

Keywords: Human papilloma virus; Laryngeal neoplasm; Uterine cervical neoplasm.