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Multicenter Study
. 2020 Oct;35(10):2897-2906.
doi: 10.1007/s11606-020-05809-y. Epub 2020 Apr 16.

Modifiable Factors Associated with Non-adherence to Antihypertensive or Antihyperlipidemic Drugs Are Dissimilar: a Multicenter Study Among Patients with Diabetes in Indonesia

Sofa D Alfian  1   2   3 , Nurul Annisa  4 , Fajriansyah Fajriansyah  5 , Dyah A Perwitasari  6 , Rizky Abdulah  7   8 , Eelko Hak  9 , Petra Denig  10
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Free PMC article
Multicenter Study

Modifiable Factors Associated with Non-adherence to Antihypertensive or Antihyperlipidemic Drugs Are Dissimilar: a Multicenter Study Among Patients with Diabetes in Indonesia

Sofa D Alfian et al. J Gen Intern Med. 2020 Oct.
Free PMC article

Abstract

Background: To develop targeted and tailored interventions for addressing medication non-adherence, it is important to identify underlying factors.

Objective: To identify factors associated with non-adherence as well as subtypes of non-adherence to antihypertensive or antihyperlipidemic drugs among patients with type 2 diabetes in Indonesia.

Design: An observational multicenter cross-sectional survey.

Participants: Patients with type 2 diabetes using either antihypertensive or antihyperlipidemic drugs in four regions in Indonesia.

Main measures: Non-adherence and its subtypes of intentional and unintentional non-adherence were assessed using the Medication Adherence Report Scale. Necessity and concern beliefs were assessed with the Beliefs about Medicines Questionnaire. We applied binary and multinomial logistic regression to assess associations of medication beliefs, sociodemographic factors, and clinical-related factors to non-adherence and report odds ratios (OR) with 95% confidence intervals (CI).

Key results: Of 571 participating patients (response rate 97%), 45.5% and 52.7% were non-adherent to antihypertensive and antihyperlipidemic drugs, respectively. Older age was associated with non-adherence to antihypertensive drugs (60-69 years) (OR, 5.65; 95% CI, 2.68-11.92), while higher necessity beliefs (OR, 0.92; 95% CI, 0.88-0.95) were associated with less non-adherence. Factors associated with non-adherence to antihyperlipidemic drugs were female gender (OR, 1.84; 95% CI, 1.03-3.27) and higher concern beliefs (OR, 1.10; 95% CI, 1.03-1.18), while higher necessity beliefs (OR, 0.89; 95% CI, 0.83-0.96) were associated with less non-adherence.

Conclusions: The main factors associated with non-adherence to antihypertensive and antihyperlipidemic drugs are modifiable. In general, beliefs about the necessity of the drug are important but for antihyperlipidemic drugs concerns are important as well. Healthcare providers should pay attention to identify and address medication beliefs during patient counselling.

Keywords: blood pressure–lowering medication; diabetes mellitus; lipid-lowering medication; medication beliefs; medication non-adherence.

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Conflict of interest statement

The authors declare that they do not have a conflict of interest.

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References

    1. Islam SMS, Purnat TD, Phuong NTA, Mwingira U, Schacht K, Fröschl G. Non-Communicable Diseases (NCDs) in developing countries: a symposium report. Global Health. 2014;10:1–7. doi: 10.1186/s12992-014-0081-9. - DOI - PMC - PubMed
    1. International Diabetes Federation (IDF). IDF Diabetes Atlas. http://www.diabetesatlas.org/resources/2017-atlas.html. Published 2017.
    1. Sarwar N, Gao P, Kondapally Seshasai SR, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Lancet. 2010;375(9733):2215–2222. doi: 10.1016/S0140-6736(10)60484-9. - DOI - PMC - PubMed
    1. Einarson TR, Acs A, Ludwig C, Panton UH. Prevalence of cardiovascular disease in type 2 diabetes: A systematic literature review of scientific evidence from across the world in 2007–2017. Cardiovasc Diabetol. 2018;17(1). doi:10.1186/s12933-018-0728-6 - PMC - PubMed
    1. American Diabetes Association. 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2019. Diabetes Care. 2019;42(Supplement 1):S103-S123. doi:10.2337/dc19-S010 - PubMed

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