Just Took a DNA Test, Turns Out 100% Not That Phase

Mol Cell. 2020 Apr 16;78(2):193-194. doi: 10.1016/j.molcel.2020.03.029.


Heterochromatin protein 1 (HP1) has been proposed to drive heterochromatin formation by liquid-liquid phase separation. In this issue of Molecular Cell, however, Erdel et al. establish that heterochromatin can adopt digital compaction states that are independent of HP1 phase separation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly
  • Chromobox Protein Homolog 5
  • Chromosomal Proteins, Non-Histone*
  • DNA
  • Heterochromatin*
  • Mice


  • Chromosomal Proteins, Non-Histone
  • Heterochromatin
  • Chromobox Protein Homolog 5
  • DNA