Experimental traumatic brain injury does not lead to lung infection

Mujun Sun; Rhys D Brady; Brooke Wanrooy; Richelle Mychasiuk; Glenn R Yamakawa; Pablo M Casillas-Espinosa; Connie H Y Wong; Sandy R Shultz; Stuart J McDonald

doi:10.1016/j.jneuroim.2020.577239

Experimental traumatic brain injury does not lead to lung infection

J Neuroimmunol. 2020 Jun 15;343:577239. doi: 10.1016/j.jneuroim.2020.577239. Epub 2020 Apr 9.

Authors

Mujun Sun¹, Rhys D Brady², Brooke Wanrooy³, Richelle Mychasiuk⁴, Glenn R Yamakawa⁵, Pablo M Casillas-Espinosa⁶, Connie H Y Wong⁷, Sandy R Shultz⁸, Stuart J McDonald⁹

Affiliations

¹ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address: mujun.sun@monash.edu.
² Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia; Department of Medicine, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address: rhys.brady@monash.edu.
³ Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC 3168, Australia. Electronic address: brooke.wanrooy1@monash.edu.
⁴ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address: richelle.mychasiuk@monash.edu.
⁵ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia. Electronic address: Glenn.Yamakawa@monash.edu.
⁶ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia; Department of Medicine, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address: pablo.casillas-espinosa@monash.edu.
⁷ Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC 3168, Australia. Electronic address: connie.wong@monash.edu.
⁸ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia; Department of Medicine, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address: sandy.shultz@monash.edu.
⁹ Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia; Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: stuart.mcdonald@monash.edu.

PMID: 32302792
DOI: 10.1016/j.jneuroim.2020.577239

Abstract

Traumatic brain injury (TBI) patients often experience post-traumatic infections, especially in the lung. Pulmonary infection is associated with unfavorable outcomes and increased mortality rates in TBI patients; however, our understanding of the underlying mechanisms is poor. Here we used a lateral fluid percussion injury (LFPI) model in rats to investigate whether TBI could lead to spontaneous lung infection. Analysis of bacterial load in lung tissue indicated no occurrence of spontaneous lung infection at 24 h, 48 h, and 7 d following LFPI. This may suggest that exogenous infectious agents play a crucial role in post-TBI infection in patients.

Keywords: Lower respiratory tract infection; Pneumonia; Pulmonary infection; Spleen; TBI.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Injuries, Traumatic / complications*
Male
Rats
Rats, Sprague-Dawley
Respiratory Tract Infections*