Limbic encephalitis in a neuroscientist: CASPR 2 antibody-associated disease after antigen exposure

Björn Ryberg; Andreas Arvidsson; My Bergkvist; Petra Nilsson

doi:10.1016/j.jneuroim.2020.577231

Limbic encephalitis in a neuroscientist: CASPR 2 antibody-associated disease after antigen exposure

J Neuroimmunol. 2020 Jun 15:343:577231. doi: 10.1016/j.jneuroim.2020.577231. Epub 2020 Apr 1.

Authors

Björn Ryberg¹, Andreas Arvidsson², My Bergkvist², Petra Nilsson²

Affiliations

¹ Division of Neurology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, SE-221 85 Lund, Sweden. Electronic address: bryb@telia.com.
² Division of Neurology, Department of Clinical Sciences Lund, Lund University, Skane University Hospital, SE-221 85 Lund, Sweden.

PMID: 32302793
DOI: 10.1016/j.jneuroim.2020.577231

Abstract

Autoimmune limbic encephalitis is part of CASPR 2 antibody-associated disease. A man with this rare disorder and a very high antibody titre had a unique history of laboratory exposure to the antigen. Together with earlier observations this case calls for caution in laboratory handling of nerve tissue.

Keywords: Antigen exposure; CASPR 2 antibody; Immunotherapy; Limbic encephalitis.

Publication types

Case Reports

MeSH terms

Aged
Autoantibodies / immunology
Autoantigens / immunology
Autoimmune Diseases / etiology*
Autoimmune Diseases / immunology*
Humans
Limbic Encephalitis / etiology*
Limbic Encephalitis / immunology*
Male
Medical Laboratory Personnel*
Membrane Proteins / immunology*
Nerve Tissue Proteins / immunology*
Occupational Exposure / adverse effects*

Substances

Autoantibodies
Autoantigens
CNTNAP2 protein, human
Membrane Proteins
Nerve Tissue Proteins

Supplementary concepts

Autoimmune limbic encephalitis