Clinical characteristics and risk assessment of newborns born to mothers with COVID-19

J Clin Virol. 2020 Jun;127:104356. doi: 10.1016/j.jcv.2020.104356. Epub 2020 Apr 10.

Abstract

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas.

Objective: Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women.

Methods: We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020.

Results: 4 of the 7 newborns were late preterm with gestational age between 36 weeks and 37 weeks, and the other 3 were full-term infants. The average birth weight was 2096 ± 660 g. All newborns were born without asphyxia. 2 premature infants performed mild grunting after birth, but relieved rapidly with non-invasive continuous positive airway pressure (nCPAP) ventilation. 3 cases had chest X-ray, 1 was normal and 2 who were supported by nCPAP presented mild neonatal respiratory distress syndrome (NRDS). Samples of pharyngeal swab in 6 cases, amniotic fluid and umbilical cord blood in 4 cases were tested by qRT-PCR, and there was no positive result of SARS-CoV-2 nucleic acid in all cases.

Conclusions: The current data show that the infection of SARS-CoV-2 in late pregnant women does not cause adverse outcomes in their newborns, however, it is necessary to separate newborns from mothers immediately to avoid the potential threats.

Keywords: COVID-19; Clinical features; Mother-to-child vertical transmission; Newborn; Pregnant woman; SARS-CoV-2.

MeSH terms

  • Amniotic Fluid / virology
  • Betacoronavirus
  • Birth Weight
  • COVID-19
  • China / epidemiology
  • Continuous Positive Airway Pressure
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / epidemiology
  • Female
  • Fetal Blood / virology
  • Gestational Age
  • Humans
  • Infant Health
  • Infant, Newborn
  • Infant, Premature
  • Infectious Disease Transmission, Vertical*
  • Male
  • Pandemics
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / epidemiology
  • Pregnancy
  • Pregnancy Complications, Infectious / virology*
  • Prospective Studies
  • Risk Assessment
  • SARS-CoV-2
  • Thorax / diagnostic imaging
  • Thorax / virology
  • Tomography, X-Ray Computed