What Do We Know About Clodronate Now? A Medical and Veterinary Perspective

J Equine Vet Sci. 2020 May:88:102874. doi: 10.1016/j.jevs.2019.102874. Epub 2019 Nov 23.


There has recently been some controversy over the use of bisphosphonates in horses and some confusion regarding the different classes of bisphosphonates and the differences between the mechanism of actions and effects of each class. This review article explores the different bisphosphonate classes and their different effects and mechanisms of action based on research from both the human and equine veterinary fields. This collaborative review between veterinary surgeons and medical doctors describes the latest use of bisphosphonates in humans and horses, including safety aspects, and allows comparisons to be drawn between the two fields. Potential future uses of bisphosphonates are also discussed.

Keywords: Bisphosphonate; Clodronate; Horse; Lameness; Navicular syndrome; Osteoarthritis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Clodronic Acid* / therapeutic use
  • Diphosphonates* / adverse effects
  • Horses


  • Diphosphonates
  • Clodronic Acid