Increased frequencies of Sm and nRNP autoantibodies in American blacks compared to whites with systemic lupus erythematosus

J Rheumatol. 1988 Dec;15(12):1773-6.

Abstract

Frequencies of autoantibodies to Sm, nRNP, Ro (SSA) and La (SSB) were determined by countercurrent immunoelectrophoresis (CIE) and/or enzyme linked immunosorbent assays (ELISA) in 106 whites and 60 blacks with systemic lupus erythematosus. Anti-Sm occurred significantly more frequently in blacks (25%) than whites (10%) (p = 0.02), as did anti-nRNP (40% versus 23%; p = 0.03). By CIE, anti-Sm and/or nRNP occurred in 47% of blacks and 24% of whites (p = 0.004), and by ELISA the Sm/nRNP complex was detected in 52% of blacks versus 26% of whites (p = 0.003). Antibodies to Ro and La occurred with equal frequencies between the races.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoantibodies / analysis*
  • Autoantigens / immunology*
  • Blacks*
  • Counterimmunoelectrophoresis
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins*
  • Ribonucleoproteins, Small Nuclear*
  • Whites*
  • snRNP Core Proteins

Substances

  • Autoantibodies
  • Autoantigens
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • SS-A antigen
  • SS-B antigen
  • snRNP Core Proteins