Survival of nasopharyngeal cancer in national referral hospital of Indonesia: A study on radiotherapy patients

Oral Oncol. 2020 Jul;106:104707. doi: 10.1016/j.oraloncology.2020.104707. Epub 2020 Apr 16.

Abstract

Introduction: Nasopharyngeal cancer in Indonesia has a poor survival rate and there is only few studies regarding nasopharyngeal cancer in Indonesia. Therefore, this study was made to present Indonesian nasopharyngeal cancer data with special focus on survival of nasopharyngeal cancer profile that receives radiation therapy.

Methods: This was a retrospective study conducted in the Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital (RSCM). Moreover, survival analysis was done using Kaplan Meier, log rank and cox regression test.

Results: A total of 398 patients were included with the median follow-up time of 16 (0-65) months. The 3-year survival in patients with stage I-III was >50% while the survival of 5 years was >50% only in early stage patients. The median survival for men was 46 months and for women 42 months. For OTT ≤ 49 days survival of 3 years and 5 years is 67.1%. Stage III-IVB, size N2-N3, and overall treatment time >49 days were the prognostic factors for nasopharyngeal cancer patients. After multivariate analysis, only stage III-IVB was statistically significant as a prognostic factor independent of survival.

Conclusion: Most of nasopharyngeal cancer patient came in advanced stage. The median time needed for patients to get radiation therapy and median OTT were good. Only stage III-IVB was statistically significant as a prognostic factor independent of survival.

Keywords: Cancer; Nasopharyngeal cancer; Survival.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Female
  • Humans
  • Indonesia
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / mortality*
  • Patients
  • Radiation Oncology / methods*
  • Referral and Consultation
  • Retrospective Studies
  • Survival Analysis
  • Survival Rate
  • Treatment Outcome
  • Young Adult