A single-center blinded randomized clinical trial to evaluate the anti-aging effects of a novel HSF™-based skin care formulation

J Cosmet Dermatol. 2020 Nov;19(11):2936-2945. doi: 10.1111/jocd.13356. Epub 2020 Apr 19.


Background: Similar to chronic wounds, skin aging is characterized by dysfunction of key cellular regulatory pathways. The hypoxia-inducible factor-1 alpha (HIF-1α) pathway was linked to both conditions. Recent evidence suggests that modulating this pathway can rejuvenate aged fibroblasts and improve skin regeneration. Here, we describe the application of a novel HIF stimulating factor (HSF™)-based formulation for skin rejuvenation.

Methods: Over a period of 6 weeks using a split-face study design, the effects on skin surface profile, skin moisture, and transepidermal water loss were determined in 32 female subjects (mean age 54, range 32-67 years) by Fast Optical in vivo Topometry of Human Skin (FOITSHD ), Corneometer, and Tewameter measurements. In addition, a photo documentation was performed for assessment by an expert panel and a survey regarding subject satisfaction was conducted.

Results: No negative skin reactions of dermatological relevance were documented for the test product. A significant reduction in skin roughness could be demonstrated. The clinical evaluation of the images using a validated method confirmed significant improvement of wrinkles, in particular of fine wrinkles, lip wrinkles, and crow's feet. A significant skin moisturizing effect was detected while skin barrier function was preserved. The HSF™-based skin care formulation resulted in a self-reported 94% satisfaction rate.

Conclusion: With no negative skin reactions and highly significant effects on skin roughness, wrinkles, and moisturization, the HSF™-based skin care formulation achieved very satisfying outcomes in this clinical trial. Given the favorable results, this approach represents a promising innovation in aesthetic and regenerative medicine.

Keywords: HIF stimulating factor (HSF™); anti-aging; cosmetics; hypoxia-inducible factor-1 alpha (HIF-1α); regenerative medicine; skin care.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aging*
  • Female
  • Humans
  • Middle Aged
  • Rejuvenation
  • Skin
  • Skin Aging*
  • Skin Care

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