Abstract
Early availability of the sequence, the genetic material of SARS-CoV-2 (the virus that causes COVID-19), has prompted efforts towards identifying a safe and effective vaccine in the current public health emergency. To that end, understanding the pathophysiology of disease is crucial for scientists around the world. Since conventional vaccine development and manufacturing may take several years, it is important to think about alternative strategies that we could use to mitigate imminent catastrophe. We hope that this article will open up new avenues and provide insights that could potentially save hundreds of lives affected by COVID-19.
Keywords:
2019-nCoV; COVID-19; China; MERS-CoV; SARS-CoV; SARS-CoV-2; Wuhan; coronavirus.
MeSH terms
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Adenosine Monophosphate / analogs & derivatives
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Adenosine Monophosphate / therapeutic use
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Alanine / analogs & derivatives
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Alanine / therapeutic use
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Antiviral Agents / therapeutic use
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Betacoronavirus / drug effects
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Betacoronavirus / genetics*
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COVID-19
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China / epidemiology
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Communicable Disease Control / methods
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Coronavirus Infections / diagnosis
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Coronavirus Infections / drug therapy*
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Coronavirus Infections / epidemiology
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Coronavirus Infections / prevention & control*
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Genome, Viral / genetics
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Humans
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Middle East Respiratory Syndrome Coronavirus / genetics
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Pandemics / prevention & control*
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Pneumonia, Viral / diagnosis
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Pneumonia, Viral / drug therapy*
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Pneumonia, Viral / epidemiology
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Pneumonia, Viral / prevention & control*
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SARS-CoV-2
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Serine Proteinase Inhibitors / therapeutic use
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Severe acute respiratory syndrome-related coronavirus / genetics
Substances
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Antiviral Agents
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Serine Proteinase Inhibitors
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remdesivir
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Adenosine Monophosphate
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Alanine