Impact of Renal Transplantation and Immunosuppressive Therapy on Muscle Strength, Functional Capacity, and Quality of Life: A Longitudinal Study

Transplant Proc. 2020 Jun;52(5):1279-1283. doi: 10.1016/j.transproceed.2020.02.038. Epub 2020 Apr 16.

Abstract

Renal transplantation is the best long-term treatment option compared with maintenance dialysis in patients with chronic kidney disease. This treatment should be combined with immunosuppressive drugs to obtain positive effects; however, the adverse effects of these medications in the respiratory and peripheral muscle strength, functional capacity, and quality of life of patients remain unknown.

Objective: The objective of this study is to evaluate the respiratory and peripheral muscle strength, functional capacity, and quality of life of patients undergoing renal transplantation in the preoperative period and during the first 6 months of postoperative period.

Methods: The respiratory and peripheral muscle strength, quality of life, and functional capacity of 40 patients were evaluated from the pretransplant period to 6 months post-renal transplantation.

Results: Compared with the preoperative period, the patients experienced improvement of the respiratory and peripheral strength 6 months after transplant (maximal inspiratory pressure 44% and maximal expiratory pressure 28.96%, handgrip 13.81%, and lower limbs 26.95%) and also in the quality of life.

Conclusion: We conclude that 6 months after transplant, patients showed improvement in respiratory and peripheral muscle strength and quality of life, but even with the improvement, patients presented an unsatisfactory quality of life and muscle strength, regardless of immunosuppressive therapy.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Female
  • Hand Strength
  • Humans
  • Immunosuppression Therapy / adverse effects*
  • Kidney Transplantation / adverse effects*
  • Longitudinal Studies
  • Male
  • Maximal Respiratory Pressures
  • Middle Aged
  • Muscle Strength / physiology*
  • Postoperative Period
  • Quality of Life*
  • Renal Insufficiency, Chronic / physiopathology*
  • Renal Insufficiency, Chronic / surgery
  • Respiratory Muscles / physiopathology