ILC3s: Rhythmic Keepers of Gut Integrity at Mealtime

Trends Immunol. 2020 May;41(5):364-366. doi: 10.1016/ Epub 2020 Apr 16.


Cyclically, during the day, increased permeability of the intestinal epithelial barrier, allowing nutrient uptake, must be compensated for, to achieve increased protection against potentially harmful components. Seillet et al. demonstrate that, upon food intake, enteric neuron-derived VIP promotes anticipatory mucosal immunity by inducing ILC3s to produce protective IL-22.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Gastrointestinal Microbiome*
  • Humans
  • Immunity, Mucosal
  • Intestinal Mucosa
  • Neuropeptides*
  • Permeability


  • Neuropeptides