Automatic Background Removal and Correction of Systematic Error Caused by Noise Expecting Bio-Raman Big Data Analysis

Anal Sci. 2020 May 10;36(5):511-514. doi: 10.2116/analsci.20C005. Epub 2020 Apr 17.

Abstract

Spectral pretreatments, such as background removal from Raman big data, are crucial to have a smooth link to advanced spectral analysis. Recently, we developed an automated background removal method, where we considered the shortest length of a spectrum by changing the scaling factor of the background spectrum. Here, we propose a practical way to correct the systematic error caused by noise from measurements. This correction has been realized to be more effective and accurate for automatic background removal.

Keywords: Background removal; Raman; analysis; big data; bio-Raman; correction; noise; subtraction; systematic error.