Bioactivities and Future Perspectives of Chaetoglobosins

Evid Based Complement Alternat Med. 2020 Mar 24:2020:8574084. doi: 10.1155/2020/8574084. eCollection 2020.

Abstract

Chaetoglobosins belonging to cytochalasan alkaloids represent a large class of fungal secondary metabolites. To date, around 100 chaetoglobosins and their analogues have been isolated and identified over the years from a variety of fungi, mainly from the fungus Chaetomium globosum. Studies have found that chaetoglobosins possess a broad range of biological activities, including antitumor, antifungal, phytotoxic, fibrinolytic, antibacterial, nematicidal, anti-inflammatory, and anti-HIV activities. This review will comprehensively summarize the biological activities and mechanisms of action of nature-derived chaetoglobosins.

Publication types

  • Review