Methotrexate (MTX) is an anti-metabolite commonly administered during chemotherapy and as an immunosuppressant for autoimmune diseases. This activity reviews the indications, mechanism of action, and contraindications for methotrexate as a treatment for neoplastic and autoimmune conditions. Adverse events, off-label uses, pharmacokinetics, administration methods, and key monitoring considerations are discussed to optimize patient outcomes. Relevant drug interactions and clinical toxicology are also highlighted to enhance safe and effective use.
Copyright © 2026, StatPearls Publishing LLC.