The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial

J Altern Complement Med. 2020 Jun;26(6):529-536. doi: 10.1089/acm.2019.0325. Epub 2020 Apr 20.


Background: Centella asiatica, a medicinal plant, has been used traditionally to promote wound healing. Its efficacy on promoting postlaser resurfacing wound healing is lacking. Methods: Thirty individuals with facial acne scars underwent a treatment with 2940 nm Er:YAG laser. Half side of the face was randomized to receive 0.05% w/w ECa 233 gel, a standardized extract of C. asiatica, and the other half a placebo gel. The gels were applied four times daily for 7 days then twice daily for 3 months. Erythema, melanin, and texture index (TI) from Antera3D,® and skin biophysics were obtained at baseline, days 2, 4, and 7, then every 2 weeks for the first month, and every month for 3 months. Three blinded dermatologists assessed the photographs and provided a grading scale of wound appearances. Results: The ECa 233 treated side exhibited significantly less erythema index over total follow-up by 0.03 U (coefficient = -0.03 [95% CI -0.06 to -0.0006]; p = 0.046). In keeping with the physicians' assessment that showed significantly higher improvements in skin erythema at days 2, 4, and 7 (p = 0.009, 0.0061, 0.012), crusting at days 2 (p = 0.02), and general wound appearance at days 2, 4, and 7 (p = 0.008, 0.001, 0.044), TI showed a trend toward better outcome in the ECa 233 group. Skin biophysics did not differ between the two groups. Conclusion: ECa 233 might be an option for postlaser treatment to improve wound appearance.

Keywords: Centella asiatica; ECa 233; asiaticoside; madecassoside; postlaser; wound.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acne Vulgaris / complications
  • Acne Vulgaris / therapy*
  • Administration, Cutaneous
  • Adult
  • Centella
  • Cicatrix / etiology
  • Cicatrix / therapy*
  • Combined Modality Therapy
  • Double-Blind Method
  • Face
  • Female
  • Humans
  • Laser Therapy*
  • Male
  • Plant Extracts
  • Triterpenes / therapeutic use*
  • Wound Healing / drug effects*


  • Centella asiatica extract
  • Plant Extracts
  • Triterpenes