Guillain Barre syndrome associated with COVID-19 infection: A case report

J Clin Neurosci. 2020 Jun;76:233-235. doi: 10.1016/j.jocn.2020.04.062. Epub 2020 Apr 15.


Novel outbreak with coronavirus 2019 began since 31 December 2019. Coronaviruses can cause multiple systemic infections that respiratory complications are the most obvious symptoms. In this report, we describe the symptoms of Guillain Barre syndrome (GBS) in one infected patient with COVID-19, for the first time. We reported a 65-years- old male patient with complaints of acute progressive symmetric ascending quadriparesis. Two weeks prior to hospitalization, the patient suffered from cough, fever, and RT-PCR was reported positive for COVID-19 infection. The electrodiagnostic test showed that the patient is an AMSAN variant of GBS. COVID-19 stimulates inflammatory cells and produces various inflammatory cytokines and as a result, it creates immune-mediated processes. GBS is an immune-mediated disorder and molecular mimicry as a mechanism of autoimmune disorder plays an important role in creating it. It is unclear whether COVID-19 induces the production of antibodies against specific gangliosides. Further investigations should be conducted about the mechanism of GBS in patients with COVID-19, in the future.

Keywords: COVID-19; Case report; Guillain Barre syndrome; Neuropathy; Novel coronavirus.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections / complications*
  • Guillain-Barre Syndrome / diagnosis
  • Guillain-Barre Syndrome / virology*
  • Humans
  • Male
  • Pandemics
  • Pneumonia, Viral / complications*
  • SARS-CoV-2