A Novel Molecular Pathway of Plaque Vulnerability Reveals a Cholesterol-Independent Effect of Statins and Supports Inflammation as a Therapeutic Target

Can J Cardiol. 2020 Nov;36(11):1710-1713. doi: 10.1016/j.cjca.2020.02.068. Epub 2020 Feb 15.

Authors

Pauline Mury¹, Jocelyn Dupuis², Eric Thorin³

Affiliations

¹ Faculty of Medicine, Department of Pharmacology and Physiology, University of Montreal, Montreal, Québec, Canada; Montreal Heart Institute, Research Center, Montreal, Québec, Canada. Electronic address: pauline.mury@umontreal.ca.
² Montreal Heart Institute, Research Center, Montreal, Québec, Canada; Faculty of Medicine, Department of Medicine, University of Montreal, Montreal, Québec, Canada.
³ Faculty of Medicine, Department of Pharmacology and Physiology, University of Montreal, Montreal, Québec, Canada; Montreal Heart Institute, Research Center, Montreal, Québec, Canada; Faculty of Medicine, Department of Surgery, University of Montreal, Montreal, Québec, Canada.

PMID: 32315602
DOI: 10.1016/j.cjca.2020.02.068

No abstract available

Publication types

Editorial
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cholesterol
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
Inflammation / drug therapy
MicroRNAs*
Plaque, Atherosclerotic* / drug therapy
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Substances

CSF2RA protein, human
Hydroxymethylglutaryl-CoA Reductase Inhibitors
MIRN532 microRNA, human
MicroRNAs
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Cholesterol