Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults

Nutrients. 2020 Apr 17;12(4):1115. doi: 10.3390/nu12041115.


Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses. Ten healthy adults participated in a randomised, controlled, double-blind, crossover trial in which they consumed a mixed-meal containing either nucleotide-depleted mycoprotein (L-NU) or high-nucleotide mycoprotein (H-NU) on two separate visits. Blood samples were collected in the postabsorptive state and throughout a 24 h postprandial period, and were used to determine circulating uric acid, glucose, and insulin concentrations. Mixed meal ingestion had divergent effects on serum uric acid concentrations across conditions (time x condition interaction; P < 0.001), with L-NU decreasing transiently (from 45 to 240 min postprandially) by ~7% (from 279 ± 16 to 257 ± 14 µmol·L-1) and H-NU resulting in a ~12% increase (from 284 ± 13 to 319 ± 12 µmol·L-1 after 210 min), remaining elevated for 12 h and returning to baseline concentrations after 24 h. There were no differences between conditions in blood glucose or serum insulin responses, nor in indices of insulin sensitivity. The ingestion of a nucleotide-rich mixed-meal increases serum uric acid concentrations for ~12 h, but does not influence postprandial blood glucose or serum insulin concentrations.

Keywords: metabolic health; mycoprotein; nucleotides; serum uric acid.

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Cross-Over Studies
  • Diet*
  • Dietary Proteins / administration & dosage*
  • Dietary Proteins / chemistry
  • Dietary Proteins / pharmacology
  • Dietary Supplements*
  • Double-Blind Method
  • Eating / physiology*
  • Female
  • Healthy Volunteers*
  • Humans
  • Insulin / blood*
  • Male
  • Nucleotides / administration & dosage*
  • Nucleotides / pharmacology*
  • Postprandial Period*
  • Time Factors
  • Uric Acid / blood*
  • Young Adult


  • Blood Glucose
  • Dietary Proteins
  • Insulin
  • Nucleotides
  • Uric Acid